Molecular Pathology Laboratory
                        Understanding disease
                                One signal at a time....

Al-Mulla
Lab

Diagnostic
Division

 Patients'
information		 Doctors'
information		 Students' Material

Literature

 Contact us
     TESTS OFFERED  Breast
cancer		  Colorectal cancer  Ewing's sarcoma Oligodendroglioma Cytogenetics    

Diagnostic Division

Colorectal cancer

  

 

  


 
   

Microsatellite instability

  

Colon cancer: Colorectal cancer is a common disorder. The Mediterranean/Eastern population is less susceptible to it. We know that our population gets it at a younger age. We believe this is a reflection of a genetic susceptibility, which  overwhelms the environmental causes such as alcohol consumption, low roughage consumption etc. Our population is thus suited to indentify the genetic cause.

We offer microsatellite instability test based on immunohistochemistry and Bathesda criteria PCR test to our patients.   

   

 

 MLH1-MSH2-PMS2
Sequencing

 

 We perform immunohistochemitry for MLH1, MSH2, PMS2 and MSH6

Our lab performs mlh1 and  msh2 sequencing as part of the European Molecular Genetics quality assurance program

We perform Ki-Ras mutation profiling on CRC to tailor therapy. Patients with Wild-type Ki-Ras are more suited for chemical intervention

  We offer GIST mutation profiling

 

 
   

 
  CRC Genetic profiling for metastatic signature
Agilent Human Genome CGH Microarray 244K
  • 236,000+ coding and noncoding human sequences represented
  • Probes annotated against NCBI Build 36 (UCSC hg18, March 2006)
  • 8.9 KB overall median probe spacing (7.4 KB in Refseq genes)
  • 0.5 μg total genomic DNA input requirement
  • 1 x 244K slide format printed using Agilent's 60-mer SurePrint technology
  • Cost: 300 K.D per slide (1 array)
 
   
 

Copyright al-mulla.org©
2009