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Diagnostic Division

Oligodendroglioma

  

 

  

 
 

 

Fluorescence in situ hybridization using 1p36 and 19q13 LSI FISH probes are used to detect oligodendroglial phenotype.

Allelic loss of 1p is a powerful predictor of chemotherapeutic response.

Combined 1p36-19q13 deletions are highly associated with classic low-grade oligodendroglioma histology and a longer survival rate.

Perry A, Fuller CE, Banerjee R, et al. Ancillary FISH analysis for 1p and 19q status: Preliminary observations in 287 gliomas and oligodendroglioma mimics. Front Biosci. 2003;8:1-9.

Buckner JC, Gesme D Jr, O'Fallon JR, et al. Phase II trial of procarbazine, lomustine, and vincristine as initial therapy for patients with low-grade oligodendroglioma or oligoastrocytoma: Efficacy and associations with chromomosomal abnormalities. J Clin Oncol. 2003;21(2):251-255

 
   

 

  

 
   

 
    Notice the loss of 1p36 and 19q13 red signals (1 red dot in nucleus)
   
 

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